Reaction Details | |||
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Target | Phosphatidylinositol 3-kinase catalytic subunit type 3 | ||
Ligand | BDBM295033 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Glo Luminescent Kinase Assay (Kglo) for PI 3-Kinase Alpha (A), PI 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D) | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 6600±n/a nM | ||
Comments | extracted | ||
Citation | Bellenie, BR; Bloomfield, GC; Bruce, I; Culshaw, AJ; Hall, EC; Hollingworth, GJ; Neef, J; Spendiff, M; Watson, SJ Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors US Patent US10112926 Publication Date 10/30/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Phosphatidylinositol 3-kinase catalytic subunit type 3 | |||
Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 | ||
Synonyms: | BC033004 | PI3K type 3 | PIK3C3 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide 3-Kinase (PI3K), Vps34 | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVPS34 | ||
Type: | Enzyme | ||
Mol. Mass.: | 101551.30 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Recombinant human Vps34 protein was expressed as monomeric GST-fusion and purified. | ||
Residue: | 887 | ||
Sequence: |
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BDBM295033 | |||
n/a | |||
Name | BDBM295033 | ||
Synonyms: | US10112926, Example 4.1 | trans 3-(6-Amino-5-(1- methyl-1H-pyrazol-4- yl)pyridin-3-yl)-N-(4- hydroxy cyclohexyl)-4- methylbenzene- sulfonamide | ||
Type | Small organic molecule | ||
Emp. Form. | C22H27N5O3S | ||
Mol. Mass. | 441.546 | ||
SMILES | Cc1ccc(cc1-c1cnc(N)c(c1)-c1cnn(C)c1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:24.26,wD:27.30,(-4.52,5,;-4.52,3.46,;-5.85,2.69,;-5.85,1.15,;-4.52,.38,;-3.19,1.15,;-3.19,2.69,;-1.85,3.47,;-1.85,5.01,;-.52,5.77,;.82,5.01,;2.15,5.78,;.82,3.47,;-.52,2.7,;2.15,2.69,;2.15,1.15,;3.61,.68,;4.52,1.92,;6.06,1.92,;3.61,3.17,;-4.52,-1.16,;-6.06,-1.16,;-2.98,-1.16,;-4.52,-2.7,;-3.19,-3.47,;-1.85,-2.7,;-.52,-3.47,;-.52,-5.01,;.82,-5.78,;-1.85,-5.78,;-3.19,-5.01,)| | ||
Structure |