Reaction Details | |||
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Target | Phosphatidylinositol 3-kinase catalytic subunit type 3 | ||
Ligand | BDBM295047 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Glo Luminescent Kinase Assay (Kglo) for PI 3-Kinase Alpha (A), PI 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D) | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | >10000±n/a nM | ||
Comments | extracted | ||
Citation | Bellenie, BR; Bloomfield, GC; Bruce, I; Culshaw, AJ; Hall, EC; Hollingworth, GJ; Neef, J; Spendiff, M; Watson, SJ Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors US Patent US10112926 Publication Date 10/30/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Phosphatidylinositol 3-kinase catalytic subunit type 3 | |||
Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 | ||
Synonyms: | BC033004 | PI3K type 3 | PIK3C3 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide 3-Kinase (PI3K), Vps34 | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVPS34 | ||
Type: | Enzyme | ||
Mol. Mass.: | 101551.30 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Recombinant human Vps34 protein was expressed as monomeric GST-fusion and purified. | ||
Residue: | 887 | ||
Sequence: |
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BDBM295047 | |||
n/a | |||
Name | BDBM295047 | ||
Synonyms: | Diastereomers of 3- (6-Amino-5-(3- methyl-1,2,4- oxadiazol-5- yl)pyridin-3-yl)-N-(3- hydroxy cyclobutyl)-4- methylbenzene sulfonamide hydrochloride | US10112926, Example 5.5 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H21N5O4S | ||
Mol. Mass. | 415.466 | ||
SMILES | Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CC(O)C1 |(6.66,-.88,;5.89,.45,;6.8,1.7,;5.89,2.95,;4.43,2.47,;4.43,.93,;3.09,3.24,;1.76,2.47,;.43,3.24,;.43,4.78,;1.76,5.55,;3.09,4.78,;4.43,5.55,;-.91,2.47,;-.91,.93,;-2.24,.16,;-3.58,.93,;-3.58,2.47,;-2.24,3.24,;-2.24,4.78,;-2.24,-1.38,;-3.78,-1.38,;-.7,-1.38,;-2.24,-2.92,;-3.58,-3.69,;-5.06,-3.29,;-5.46,-4.78,;-6.8,-5.55,;-3.97,-5.18,)| | ||
Structure |