Ki Summary

Reaction Details

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Target

Phosphatidylinositol 4-kinase beta

Ligand

BDBM295058

Substrate/Competitor

n/a

Meas. Tech.

Kinase Glo Luminescent Kinase Assay (Kglo) for PI 3-Kinase Alpha (A), PI 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D)

7.5±n/a

Temperature

298.15±n/a K

IC50

5300±n/a nM

Comments

extracted

Citation

Bellenie, BR; Bloomfield, GC; Bruce, I; Culshaw, AJ; Hall, EC; Hollingworth, GJ; Neef, J; Spendiff, M; Watson, SJ Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors US Patent US10112926 Publication Date 10/30/2018

More Info.:

Get all data from this article, Assay Method

Phosphatidylinositol 4-kinase beta

Name:

Phosphatidylinositol 4-kinase beta

Synonyms:

Type:

Protein

Mol. Mass.:

91373.30

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

816

Sequence:

MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVK
LLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRR
QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLL
NMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLI
LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVEN
EDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLN
HKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPE
NRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCD
NISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEK
VRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI
LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGY
CLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSM
TEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM

BDBM295058

n/a

Name

BDBM295058

Synonyms:

US10112926, Example 12 | trans 3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-N-(4-hydroxy-cyclohexyl)-4-methyl-benzenesulfonamide, hydrochloride salt

Type

Small organic molecule

Emp. Form.

C21H25N5O4S

Mol. Mass.

443.519

SMILES

Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:24.26,wD:27.30,(7.05,-.65,;6.28,.68,;7.19,1.93,;6.28,3.17,;4.82,2.69,;4.82,1.15,;3.48,3.47,;2.15,2.69,;.82,3.47,;.82,5,;2.15,5.78,;3.48,5,;4.82,5.78,;-.52,2.69,;-.52,1.15,;-1.85,.38,;-3.19,1.15,;-3.19,2.69,;-1.85,3.47,;-1.85,5,;-1.85,-1.15,;-.31,-1.15,;-3.39,-1.15,;-1.85,-2.69,;-3.19,-3.47,;-3.19,-5,;-4.52,-5.78,;-5.85,-5,;-7.19,-5.78,;-5.85,-3.47,;-4.52,-2.69,)|

Structure