| Reaction Details |
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 | Report a problem with these data |
| Target | Chitotriosidase-1 |
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| Ligand | BDBM349961 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HumanCHIT1 Activity Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Mazur, M; Koralewski, R; Borek, B; Olejniczak, S; Czestkowski, WJ; Piotrowicz, MC; Olczak, JP; Golebiowski, AA; Bartoszewicz, A; Maziarz, E; Kowalski, ML Substituted amino triazoles useful as human chitinase inhibitors US Patent US10538508 Publication Date 1/21/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Chitotriosidase-1 |
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| Name: | Chitotriosidase-1 |
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| Synonyms: | CHIT1 | CHIT1_HUMAN | Chitinase 1 | Chitinase-1 | Chitotriosidase | Chitotriosidase-1 | Chitotriosidase-1 (CHIT1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51682.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13231 |
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| Residue: | 466 |
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| Sequence: | MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAG
MTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFV
NSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLL
SAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAAS
LNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGM
LAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWAL
DLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFC
QGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
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| BDBM349961 |
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| n/a |
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| Name | BDBM349961 |
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| Synonyms: | 3-(4-((2S,4R)-2-(4-chlorobenzyl)-4-methoxypyrrolidin-1-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine | US10208020, Example 51 | US10538508, Example 51 | US9944624, Ex. 51 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27ClN6O |
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| Mol. Mass. | 390.91 |
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| SMILES | CO[C@@H]1C[C@H](Cc2ccc(Cl)cc2)N(C1)C1CCN(CC1)c1n[nH]c(N)n1 |r| |
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| Structure | 
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