| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Ligand | BDBM430027 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| Ki | 11.8±n/a nM |
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| Citation |  Dack, KN; Owen, RM; Pryde, DC 4-(biphen-3-yl)-1H-pyrazolo[3,4-c]pyridazine derivatives of formula (I) as GABA receptor modulators for use in the treatment of epilepsy and pain US Patent US10538523 Publication Date 1/21/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Synonyms: | GABA receptor alpha-2 subunit | GABRA2 | GBRA2_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) |
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| Type: | Protein |
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| Mol. Mass.: | 51338.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47869 |
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| Residue: | 451 |
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| Sequence: | MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
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| BDBM430027 |
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| n/a |
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| Name | BDBM430027 |
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| Synonyms: | 5-[5-(1-Ethyl-1H-pyrazolo[3,4-c]pyridazin-4-yl)-2-fluorophenyl]-6-methoxy-2-methyl-2,3-dihydroisoindol-1-one | US10538523, Example 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20FN5O2 |
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| Mol. Mass. | 417.4356 |
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| SMILES | CCn1ncc2c(cnnc12)-c1ccc(F)c(c1)-c1cc2CN(C)C(=O)c2cc1OC |
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| Structure | 
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