| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
|---|
| Ligand | BDBM430188 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Ca2+ Flux Assay |
|---|
| IC50 | 410±n/a nM |
|---|
| Citation |  Conn, PJ; Lindsley, CW; Emmitte, KA; Felts, AS; Bollinger, KA 4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators US Patent US10538491 Publication Date 1/21/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 2 |
|---|
| Name: | Metabotropic glutamate receptor 2 |
|---|
| Synonyms: | GRM2_RAT | Gprc1b | Grm2 | Mglur2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 95786.41 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_105034 |
|---|
| Residue: | 872 |
|---|
| Sequence: | MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGAL
ESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAP
RASANLGQGSGSQFVPTVCNGREVVDSTTSSL
|
|
|
|---|
| BDBM430188 |
|---|
| n/a |
|---|
| Name | BDBM430188 |
|---|
| Synonyms: | 4-(4-fluorophenyl)-5-(2-((2-methylpyridin-4-yl)oxy)ethoxy)picolinamide | US10538491, Compound 118 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18FN3O3 |
|---|
| Mol. Mass. | 367.3736 |
|---|
| SMILES | Cc1cc(OCCOc2cnc(cc2-c2ccc(F)cc2)C(N)=O)ccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
