| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-alpha serine/threonine-protein kinase [E17K] |
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| Ligand | BDBM431880 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assays |
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| IC50 | 23678±3600 nM |
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| Citation |  Rauh, D; Gontla, R; Weisner, J Kinase inhibitors and their use in cancer therapy US Patent US10550114 Publication Date 2/4/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-alpha serine/threonine-protein kinase [E17K] |
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| Name: | RAC-alpha serine/threonine-protein kinase [E17K] |
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| Synonyms: | AKT1 | AKT1_HUMAN | PKB | RAC | RAC-alpha serine/threonine-protein kinase AKT1 (E17K) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55682.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31749 (E17K) |
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| Residue: | 480 |
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| Sequence: | MSDVAIVKEGWLHKRGKYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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| BDBM431880 |
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| n/a |
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| Name | BDBM431880 |
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| Synonyms: | US10550114, Compound 45 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H36N6O3 |
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| Mol. Mass. | 648.7522 |
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| SMILES | O=C(Nc1cccc(c1)C(=O)NC1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1)C(=C\C1CC1)\C#N |
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| Structure | 
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