| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-alpha serine/threonine-protein kinase |
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| Ligand | BDBM431867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assays |
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| Ki | 1.000±0.2 nM |
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| Citation |  Rauh, D; Gontla, R; Weisner, J Kinase inhibitors and their use in cancer therapy US Patent US10550114 Publication Date 2/4/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-alpha serine/threonine-protein kinase |
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| Name: | RAC-alpha serine/threonine-protein kinase |
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| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55681.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31749 |
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| Residue: | 480 |
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| Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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| BDBM431867 |
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| n/a |
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| Name | BDBM431867 |
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| Synonyms: | US10550114, Compound 1a |
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| Type | Small organic molecule |
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| Emp. Form. | C36H32N6O3 |
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| Mol. Mass. | 596.6777 |
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| SMILES | C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(Cc4ccc(cc4)-c4nc5cc[nH]c(=O)c5cc4-c4ccccc4)CC3)c2c1 |
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| Structure | 
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