| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase HCK |
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| Ligand | BDBM375280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Activity Assay |
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| IC50 | 62.2±n/a nM |
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| Citation |  Treon, SP; Buhrlage, SJ; Gray, NS; Tan, L; Yang, G Methods to treat lymphoplasmacytic lymphoma US Patent US10597387 Publication Date 3/24/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase HCK |
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| Name: | Tyrosine-protein kinase HCK |
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| Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59600.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08631 |
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| Residue: | 526 |
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| Sequence: | MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
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| BDBM375280 |
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| n/a |
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| Name | BDBM375280 |
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| Synonyms: | US10597387, Compound (I-3) | US9908872, Compound (I-3) |
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| Type | Small organic molecule |
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| Emp. Form. | C29H22F3N5O2S |
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| Mol. Mass. | 561.577 |
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| SMILES | Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(NC(=O)c3cncc(c3)-c3cccs3)c2)cc(c1)C(F)(F)F |
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| Structure | 
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