| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase-1 |
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| Ligand | BDBM290417 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 1000±n/a nM |
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| Citation |  Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent US10603330 Publication Date 3/31/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Arginase-1 |
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| Name: | Arginase-1 |
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| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34737.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_978893 |
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| Residue: | 322 |
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| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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| BDBM290417 |
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| n/a |
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| Name | BDBM290417 |
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| Synonyms: | (3R,4S)-3-amino-4-(3-boronopropyl)-1-(1,2,3,4- tetrahydroisoquinoline-3-carbonyl)pyrrolidine-3-carboxylic acid | US10098902, Example 53 | US10603330, Example 53 | US11389464, Example 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H26BN3O5 |
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| Mol. Mass. | 375.227 |
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| SMILES | N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1Cc2ccccc2CN1)C(O)=O |r| |
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| Structure | 
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