| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor [Y537S] |
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| Ligand | BDBM443443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competition Binding Assay |
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| Ki | 5.44±n/a nM |
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| Citation |  Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Selective estrogen receptor degraders US Patent US10654866 Publication Date 5/19/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor [Y537S] |
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| Name: | Estrogen receptor [Y537S] |
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| Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor (Y537S) | Estrogen receptor alpha Y537S | NR3A1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 66154.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372[Y537S] |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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| BDBM443443 |
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| n/a |
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| Name | BDBM443443 |
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| Synonyms: | US10654866, Example 8B | US11117902, Example 8B | US11634426, Example 8A |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27FN2O3 |
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| Mol. Mass. | 470.5347 |
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| SMILES | Cc1cccc-2c1O[C@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 |r| |
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| Structure | 
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