| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 |
|---|
| Ligand | BDBM444979 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Selective Inhibition Assays of Isolated Na,K-ATPase |
|---|
| Ki | 28.9±1.7 nM |
|---|
| Citation |  Karlish, SJ; Katz, A; Tal, DM; Marcovich, A Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure US Patent US10668094 Publication Date 6/2/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 |
|---|
| Name: | Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 |
|---|
| Synonyms: | Na,K-ATPase α2β1 | Na,K-ATPase alpha2beta1 | alpha2beta1FXYD1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Sodium/potassium-transporting ATPase subunit alpha-2 |
|---|
| Synonyms: | AT1A2_HUMAN | ATP1A2 | KIAA0778 | Na,K-ATPase isoform alpha-2 (α2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 112253.12 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P50993 |
|---|
| Residue: | 1020 |
|---|
| Sequence: | MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKG
LTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAME
DEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINA
EEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNI
CFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFL
GVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE
AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALS
RIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPF
NSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYM
ELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAV
GKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVNPREAKAC
VVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSP
ALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN
IPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDK
LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYG
QEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETA
LAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY
|
|
|
|---|
| Component 2 |
| Name: | Sodium/potassium-transporting ATPase subunit beta-1 |
|---|
| Synonyms: | AT1B1_HUMAN | ATP1B | ATP1B1 | Na,K-ATPase isoform beta-1 (β1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35067.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05026 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT
ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD
MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL
QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE
VKS
|
|
|
|---|
| BDBM444979 |
|---|
| n/a |
|---|
| Name | BDBM444979 |
|---|
| Synonyms: | US10668094, Compound DiP |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C44H71NO12 |
|---|
| Mol. Mass. | 806.034 |
|---|
| SMILES | CC(C)N1CCC(O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)C(CCC6C5C[C@H](O)[C@]5(C)[C@H](CC[C@]65O)C5=CC(=O)OC5)C4)O[C@H]3C)O[C@H]2C)OC(C)C1 |r,t:43| |
|---|
| Structure | 
|
|---|
Search and Browse
