| Reaction Details |
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 | Report a problem with these data |
| Target | Amyloid-beta precursor protein [672-713] |
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| Ligand | BDBM446531 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | gamma-Secretase Assay |
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| EC50 | 72.0±n/a nM |
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| Citation |  Bartels, B; Jakob-Roetne, R; Limberg, A; Neidhart, W; Ratni, H; Steiner, S; Reutlinger, M Fused pyrimidine derivatives US Patent US10669276 Publication Date 6/2/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Amyloid-beta precursor protein [672-713] |
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| Name: | Amyloid-beta precursor protein [672-713] |
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| Synonyms: | A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein aa 672-713 | Amyloid-beta protein 42 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 4512.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05067[672-713] |
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| Residue: | 42 |
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| Sequence: | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
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| BDBM446531 |
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| n/a |
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| Name | BDBM446531 |
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| Synonyms: | N2-(3-Methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4,5,5-trimethyl-7-(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | US10669276, Example 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29F3N8O |
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| Mol. Mass. | 514.546 |
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| SMILES | CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)C12CC(C1)(C2)C(F)(F)F |
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| Structure | 
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