Reaction Details |
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Target | Amyloid-beta precursor protein [672-713] |
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Ligand | BDBM446532 |
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Substrate/Competitor | n/a |
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Meas. Tech. | gamma-Secretase Assay |
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EC50 | 30.0±n/a nM |
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Citation | Bartels, B; Jakob-Roetne, R; Limberg, A; Neidhart, W; Ratni, H; Steiner, S; Reutlinger, M Fused pyrimidine derivatives US Patent US10669276 Publication Date 6/2/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Amyloid-beta precursor protein [672-713] |
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Name: | Amyloid-beta precursor protein [672-713] |
Synonyms: | A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein aa 672-713 | Amyloid-beta protein 42 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 4512.53 |
Organism: | Homo sapiens (Human) |
Description: | P05067[672-713] |
Residue: | 42 |
Sequence: | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
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BDBM446532 |
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n/a |
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Name | BDBM446532 |
Synonyms: | N2-(5-Methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-yl)-N4,5,5-trimethyl-7-(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | US10669276, Example 22 |
Type | Small organic molecule |
Emp. Form. | C25H29F3N8O |
Mol. Mass. | 514.546 |
SMILES | CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)C12CC(C1)(C2)C(F)(F)F |
Structure |
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