| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Amyloid-beta precursor protein [672-713] |
|---|
| Ligand | BDBM50465360 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | gamma-Secretase Assay |
|---|
| EC50 | 8.00±n/a nM |
|---|
| Citation |  Bartels, B; Jakob-Roetne, R; Limberg, A; Neidhart, W; Ratni, H; Steiner, S; Reutlinger, M Fused pyrimidine derivatives US Patent US10669276 Publication Date 6/2/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Amyloid-beta precursor protein [672-713] |
|---|
| Name: | Amyloid-beta precursor protein [672-713] |
|---|
| Synonyms: | A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein aa 672-713 | Amyloid-beta protein 42 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 4512.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05067[672-713] |
|---|
| Residue: | 42 |
|---|
| Sequence: | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
|
|
|
|---|
| BDBM50465360 |
|---|
| n/a |
|---|
| Name | BDBM50465360 |
|---|
| Synonyms: | CHEMBL4294948 | US10669276, Example 28 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H29FN8O2 |
|---|
| Mol. Mass. | 504.5593 |
|---|
| SMILES | COc1cc(Nc2nc3N(CC(C)(C)c3c(NCCO)n2)c2ccc(F)cc2)ccc1-n1cnc(C)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
