| Reaction Details |
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 | Report a problem with these data |
| Target | Apelin receptor |
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| Ligand | BDBM447997 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | GTPγS Binding |
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| EC50 | 0.064±n/a nM |
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| Citation |  Chen, Y; Cheng, AC; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Pattaropong, V; Swaminath, G; Kreiman, C; Moebius, DC; Sharma, A Triazole pyridyl compounds as agonists of the APJ receptor US Patent US10689367 Publication Date 6/23/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apelin receptor |
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| Name: | Apelin receptor |
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| Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42664.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35414 |
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| Residue: | 380 |
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| Sequence: | MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD
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| BDBM447997 |
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| n/a |
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| Name | BDBM447997 |
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| Synonyms: | US10689367, Example 325.0 | US10689367, Example 326.0 | US10689367, Example 327.0 | US10689367, Example 328.0 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32ClN7O5S |
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| Mol. Mass. | 566.073 |
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| SMILES | CC[C@H]([C@@H]1CCCCO1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1 |r| |
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| Structure | 
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