| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
|---|
| Ligand | BDBM448734 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | 24.2±n/a nM |
|---|
| Citation |  Lumeras Amador, W; Boulet, SL; Burkholder, TP; Carballares Martin, S; Gilmour, R; Hahn, PJ; Bauer, RA; Rankovic, Z Mutant IDH1 inhibitors US Patent US10696665 Publication Date 6/30/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
|---|
| Name: | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
|---|
| Synonyms: | IDH1 | IDH1 R132C | IDH1(R132C) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132C) | Isocitrate dehydrogenase 1 mutant (R132C) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (R132C) | PICD |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 46607.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75874[R132C] |
|---|
| Residue: | 414 |
|---|
| Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
|
|
|
|---|
| BDBM448734 |
|---|
| n/a |
|---|
| Name | BDBM448734 |
|---|
| Synonyms: | (S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)methyl)phenyl)ethyl) amino)pyrimidin-4-yl)- 4-ethyloxazolidin-2-one | US10696665, Example 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H32N6O3 |
|---|
| Mol. Mass. | 464.56 |
|---|
| SMILES | CC[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCN(CC3)C(=O)C=C)cc2)n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
