Reaction Details |
| Report a problem with these data |
Target | Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] |
---|
Ligand | BDBM448738 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Biochemical Assay |
---|
IC50 | 27.6±n/a nM |
---|
Citation | Lumeras Amador, W; Boulet, SL; Burkholder, TP; Carballares Martin, S; Gilmour, R; Hahn, PJ; Bauer, RA; Rankovic, Z Mutant IDH1 inhibitors US Patent US10696665 Publication Date 6/30/2020 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] |
---|
Name: | Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] |
Synonyms: | Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) | IDH1 | IDH1 R132H | IDH1(R132H) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132H) | Isocitrate dehydrogenase 1 mutant (R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (R132H) | PICD |
Type: | Protein |
Mol. Mass.: | 46641.74 |
Organism: | Homo sapiens (Human) |
Description: | Human IDH1 R132H (SEQ ID No. 2 in patent). First three are removed. Google patent parsed wrong. |
Residue: | 414 |
Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
|
|
|
BDBM448738 |
---|
n/a |
---|
Name | BDBM448738 |
Synonyms: | (S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)methyl)phenyl)ethyl) amino)-6-fluoropyrimidin- 4-yl)-4-isopropyloxazolidin- 2-one | US10696665, Example 6 |
Type | Small organic molecule |
Emp. Form. | C26H33FN6O3 |
Mol. Mass. | 496.577 |
SMILES | CC(C)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2ccc(CN3CCN(CC3)C(=O)C=C)cc2)n1 |r| |
Structure |
|