| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription intermediary factor 1-alpha |
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| Ligand | BDBM449285 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Alpha Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Bradner, J; Buckley, D; Gechijian, L Degradation of tripartite motif-containing protein 24 (TRIM24) by conjugation of TRIM24 inhibitors with E3 ligase ligand and methods of use US Patent US10702504 Publication Date 7/7/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription intermediary factor 1-alpha |
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| Name: | Transcription intermediary factor 1-alpha |
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| Synonyms: | 6.3.2.- | E3 ubiquitin-protein ligase TRIM24 | RING finger protein 82 | RNF82 | RNF82 | TIF1 | TIF1-alpha | TIF1A | TIF1A_HUMAN | TRIM24 | Transcription intermediary factor 1-alpha | Tripartite motif-containing protein 24 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 116839.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107998 |
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| Residue: | 1050 |
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| Sequence: | MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCH
QNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFAT
QVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDK
LTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQ
NQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINL
GSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQ
RQQVQRRPAPVGLPNPRMQGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRY
PPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYD
GKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQS
PNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPI
RIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETVLRS
DAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLC
CEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKL
TPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYS
KPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESE
DNKFSDDSDDDFVQPRKKRLKSIEERQLLK
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| BDBM449285 |
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| n/a |
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| Name | BDBM449285 |
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| Synonyms: | US10702504, Compound I-A10 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H58N8O13S |
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| Mol. Mass. | 1011.106 |
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| SMILES | CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cccc(c2)C(=O)NCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c1 |
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| Structure | 
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