| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM50531905 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | KOR Antagonist Assay |
|---|
| IC50 | 5.5±n/a nM |
|---|
| Citation |  Roberts, E; Guerrero, MA; Urbano, M; Rosen, H; Jones, RM; Laxamana, CM; Zhao, X; Turtle, ED Kappa opioid receptor antagonists and products and methods related thereto US Patent US10676469 Publication Date 6/9/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 42648.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41145 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
|
|
|
|---|
| BDBM50531905 |
|---|
| n/a |
|---|
| Name | BDBM50531905 |
|---|
| Synonyms: | CHEMBL4566736 | US10676469, Compound 251 | US11124504, Cpd. No. 251 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H28FN5O2 |
|---|
| Mol. Mass. | 425.4991 |
|---|
| SMILES | CCc1cc(F)c2nc(N3CCC(CC3)N[C@@H]3CCOC3)c(cc2c1)-c1nc(C)no1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
