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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Ligand | BDBM451134 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Exemplary MCL-1 Inhibitors Bind MCL-1 | ||
| Ki | 0.020±n/a nM | ||
| Citation |  Judd, AS; Kunzer, AR; Lai, C; Souers, AJ; Tao, Z; Mastracchio, A; Wang, X; Ji, C; Wendt, MD; Song, X; Doherty, GA; Penning, TD Macrocyclic MCL-1 inhibitors and methods of use US Patent US10676485 Publication Date 6/9/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Induced myeloid leukemia cell differentiation protein Mcl-1 | |||
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT | ||
| Type: | Membrane; Single-pass membrane protein | ||
| Mol. Mass.: | 37332.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07820 | ||
| Residue: | 350 | ||
| Sequence: |
| ||
| BDBM451134 | |||
| n/a | |||
| Name | BDBM451134 | ||
| Synonyms: | US10676485, Example 44 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C53H57Cl2FN6O9S | ||
| Mol. Mass. | 1044.024 | ||
| SMILES | CN1CCN(C[C@@H]2COc3ccc(OCc4ccnc(n4)[C@H]4CC[C@@H](CC4)OC[C@@H]4COCCO4)c(C[C@@H](Oc4ncnc5sc(c(-c6c(C)c(Cl)c(O2)c(Cl)c6C)c45)-c2ccc(F)cc2)C(O)=O)c3)CC1 |r,wU:37.73,6.5,21.21,wD:29.30,24.28,(15.01,6.11,;13.52,5.71,;13.13,4.22,;11.64,3.82,;10.55,4.91,;9.06,4.51,;8.66,3.03,;7.18,2.63,;4.03,5.47,;3.26,4.13,;1.72,4.13,;.95,2.8,;1.72,1.47,;.95,.13,;-.59,.13,;-1.36,1.47,;-.59,2.8,;-1.36,4.13,;-2.9,4.13,;-3.67,2.8,;-2.9,1.47,;-5.21,2.8,;-5.98,1.47,;-7.52,1.47,;-8.29,2.8,;-7.52,4.13,;-5.98,4.13,;-9.83,2.8,;-10.6,1.47,;-12.14,1.47,;-12.91,.13,;-14.45,.13,;-15.22,1.47,;-14.45,2.8,;-12.91,2.8,;3.26,1.47,;4.03,.13,;4.03,-1.41,;5.36,-2.18,;5.36,-3.72,;4.03,-4.49,;4.03,-6.03,;5.36,-6.8,;6.69,-6.03,;8.16,-6.5,;9.06,-5.26,;8.16,-4.01,;8.56,-2.53,;7.47,-1.44,;5.98,-1.04,;7.87,.05,;6.78,1.14,;9.35,.45,;9.75,1.94,;10.44,-.64,;11.93,-.24,;10.04,-2.13,;11.13,-3.22,;6.69,-4.49,;10.6,-5.26,;11.37,-6.59,;12.91,-6.59,;13.68,-5.26,;15.22,-5.26,;12.91,-3.92,;11.37,-3.92,;2.69,-2.18,;1.36,-1.41,;2.69,-3.72,;4.03,2.8,;10.95,6.4,;12.44,6.8,)| | ||
| Structure | 
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