| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf [V600E] |
|---|
| Ligand | BDBM202682 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Activity Assay |
|---|
| IC50 | 0.600±n/a nM |
|---|
| Citation |  Aversa, RJ; Barsanti, PA; Burger, MT; Dillon, MP; Dipesa, A; Hu, C; Lou, Y; Nishiguchi, GA; Pan, Y; Polyakov, VR; Ramurthy, S; Rico, AC; Setti, LQ; Smith, A; Subramanian, S; Taft, BR; Tanner, HR; Wan, L; Yusuff, N Biaryl amide compounds as kinase inhibitors US Patent US10709712 Publication Date 7/14/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase B-raf [V600E] |
|---|
| Name: | Serine/threonine-protein kinase B-raf [V600E] |
|---|
| Synonyms: | B-RAF V600E | B-Raf (V600E) | B-Raf Protein Kinase Mutant (V600E) | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF (V600E) | BRAF mutant V600E | BRAF1 | BRAF_HUMAN | P15056 | Protein mono-ADP-ribosyltransferase (PARP3) | RAF serine/threonine protein kinase (V600E) | RAFB1 | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf [V600E] | V-RAF murine sarcoma viral oncogene homologue B1 mutant (BRAF V600E) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 84474.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15056 V600E |
|---|
| Residue: | 766 |
|---|
| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATE
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
|
|
|
|---|
| BDBM202682 |
|---|
| n/a |
|---|
| Name | BDBM202682 |
|---|
| Synonyms: | US10245267, Example 38 | US10709712, Example 38 | US9242969, 27 | US9694016, 27 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H23F3N4O4S |
|---|
| Mol. Mass. | 520.524 |
|---|
| SMILES | Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)S(C)(=O)=O)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
