Ki Summary

Reaction Details

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Target

Bone morphogenetic protein receptor type-1A [198-525]

Ligand

BDBM451825

Substrate/Competitor

n/a

Meas. Tech.

ADPGlo Assay

IC50

920±n/a nM

Citation

Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10710980 Publication Date 7/14/2020

More Info.:

Get all data from this article, Assay Method

Bone morphogenetic protein receptor type-1A [198-525]

Name:

Bone morphogenetic protein receptor type-1A [198-525]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

37140.17

Organism:

Homo sapiens (Human)

Description:

aa 198-525

Residue:

328

Sequence:

AFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEK
VAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSL
YDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCC
IADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLII
WEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVL
KLMSECWAHNPASRLTALRIKKTLAKMV

BDBM451825

n/a

Name

BDBM451825

Synonyms:

US10710980, Example 54 | US10947218, Example 54

Type

Small organic molecule

Emp. Form.

C26H30N4O2

Mol. Mass.

430.542

SMILES

Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CC#C)C2 |r,wU:23.25,10.10,wD:13.14,25.27,(-4.69,4.29,;-3.36,3.52,;-2.02,4.29,;-.69,3.52,;-.69,1.98,;-2.02,1.21,;-3.36,1.98,;-4.69,1.21,;-6.03,1.98,;-4.69,-.33,;-6.03,-1.1,;-6.16,-2.64,;-7.56,-3.29,;-8.82,-2.4,;-10.04,-3.01,;-8.68,-.87,;-7.29,-.22,;.64,1.21,;.64,-.33,;1.98,-1.1,;3.31,-.33,;3.31,1.21,;1.98,1.98,;4.64,-1.1,;4.8,.43,;6.05,-.48,;7.08,-1.62,;6.31,-2.95,;7.08,-4.29,;8.51,-4.29,;10.04,-4.29,;4.8,-2.63,)|

Structure