Reaction Details | |||
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Target | Serine/threonine-protein kinase receptor R3 [166-493] | ||
Ligand | BDBM451769 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Caliper Assay | ||
IC50 | 75.0±n/a nM | ||
Citation | Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10710980 Publication Date 7/14/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase receptor R3 [166-493] | |||
Name: | Serine/threonine-protein kinase receptor R3 [166-493] | ||
Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK1)(aa 166-493) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 36974.75 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 166-493 | ||
Residue: | 328 | ||
Sequence: |
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BDBM451769 | |||
n/a | |||
Name | BDBM451769 | ||
Synonyms: | US10710980, Example 1 | US10947218, Example 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H39N5O4S | ||
Mol. Mass. | 553.716 | ||
SMILES | CS(=O)(=O)N1CCC(CC1)N1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:14.18,32.36,wD:12.13,35.40,(7.28,-6.06,;8.77,-5.66,;8.77,-7.2,;10.26,-5.27,;8.14,-4.26,;6.61,-4.1,;5.99,-2.69,;6.89,-1.44,;8.42,-1.6,;9.05,-3.01,;6.27,-.04,;7.04,1.3,;6,2.44,;4.76,3.35,;4.6,1.81,;4.76,.28,;3.26,2.58,;1.93,1.81,;.6,2.58,;.6,4.12,;1.93,4.89,;3.26,4.12,;-.74,4.89,;-.74,6.43,;-2.07,7.2,;-3.4,6.43,;-4.74,7.2,;-3.4,4.89,;-2.07,4.12,;-4.74,4.12,;-6.07,4.89,;-4.74,2.58,;-6.07,1.81,;-6.21,.28,;-7.6,-.37,;-8.86,.51,;-10.26,-.14,;-8.73,2.05,;-7.33,2.7,)| | ||
Structure |