| Reaction Details |
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 | Report a problem with these data |
| Target | Advanced glycosylation end product-specific receptor |
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| Ligand | BDBM95323 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | High-Throughput Screening Assay |
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| Kd | 0.550±0.05 nM |
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| Citation |  Schmidt, AM; Ramasamy, R; Shekhtman, A; Rai, V; Manigrasso, MB Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof US Patent US10729695 Publication Date 8/4/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Advanced glycosylation end product-specific receptor |
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| Name: | Advanced glycosylation end product-specific receptor |
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| Synonyms: | AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42800.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1339877 |
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| Residue: | 404 |
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| Sequence: | MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA
WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI
PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH
PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL
VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYS
CVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGV
ILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
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| BDBM95323 |
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| n/a |
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| Name | BDBM95323 |
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| Synonyms: | 4-[4-(2-methoxyphenyl)-6-(trifluoromethyl)-2-pyrimidinyl]morpholine | 4-[4-(2-methoxyphenyl)-6-(trifluoromethyl)pyrimidin-2-yl]morpholine | MLS000044539 | SMR000022316 | US10729695, Compound CB-7 | cid_2989573 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16F3N3O2 |
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| Mol. Mass. | 339.3123 |
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| SMILES | COc1ccccc1-c1cc(nc(n1)N1CCOCC1)C(F)(F)F |
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| Structure | 
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