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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile acid receptor | ||
| Ligand | BDBM453881 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | transient human FXR/Gal4-luciferase reporter assay | ||
| EC50 | 1.000±n/a nM | ||
| Citation |  Yoon, DS; Anumula, RK; Cheruku, S; Huang, Y; Jurica, EA; Meng, W; Nara, SJ; Narayan, R; Sistla, RK; Wu, X; Zhao, G Bridged bicyclic compounds as farnesoid X receptor modulators US Patent US10730863 Publication Date 8/4/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile acid receptor | |||
| Name: | Bile acid receptor | ||
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 55916.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96RI1 | ||
| Residue: | 486 | ||
| Sequence: |
| ||
| BDBM453881 | |||
| n/a | |||
| Name | BDBM453881 | ||
| Synonyms: | US10730863, Example 275 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H29ClN6O6 | ||
| Mol. Mass. | 581.019 | ||
| SMILES | COc1cc(cc(n1)C(O)=O)-c1noc(n1)C12CCC(CC1)(CC2)OCc1c(onc1-c1c(Cl)cnn1C)C1CC1 |(9.65,2.62,;8.21,3.17,;7.02,2.2,;5.58,2.75,;4.38,1.78,;4.62,.26,;6.06,-.29,;7.26,.68,;6.3,-1.81,;5.11,-2.78,;7.74,-2.36,;2.95,2.34,;2.55,3.82,;1.01,3.9,;.46,2.47,;1.65,1.5,;-1.03,2.07,;-2.36,.57,;-3.76,.28,;-2.63,1.56,;-.93,1.02,;.48,1.4,;-3.1,2.94,;-1.63,3.4,;-4.17,1.65,;-5.01,.37,;-6.55,.46,;-7.38,1.75,;-8.87,1.36,;-8.96,-.17,;-7.53,-.73,;-7.14,-2.22,;-5.7,-2.78,;-4.41,-1.95,;-5.79,-4.32,;-7.28,-4.71,;-8.12,-3.41,;-9.65,-3.32,;-6.82,3.19,;-5.62,4.15,;-7.05,4.71,)| | ||
| Structure | 
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