| Reaction Details |
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 | Report a problem with these data |
| Target | Oxidized low-density lipoprotein receptor 1 |
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| Ligand | BDBM454255 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | >300±n/a nM |
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| Citation |  Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Zhou, W; Robertson, AD Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof US Patent US10717733 Publication Date 7/21/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxidized low-density lipoprotein receptor 1 |
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| Name: | Oxidized low-density lipoprotein receptor 1 |
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| Synonyms: | LOX-1 | LOX1 | Lectin-like oxLDL receptor 1 | Lectin-like oxidized LDL receptor 1 | Lectin-type oxidized LDL receptor 1 | OLR1 | OLR1_BOVIN | Ox-LDL receptor 1 | bLOX-1 |
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| Type: | Protein |
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| Mol. Mass.: | 30894.65 |
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| Organism: | Bovine |
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| Description: | P79391 |
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| Residue: | 270 |
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| Sequence: | MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVS
DLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELH
RQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINS
TDELEFIQQMIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCA
YIQRGTVFAENCILTAFSICQKKANLLRAQ
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| BDBM454255 |
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| n/a |
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| Name | BDBM454255 |
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| Synonyms: | (Z)-1-(4-amino-2-fluorobut-2-en-1-yl)-3- (3-(N,N-dimethylsulfamoyl)phenyl)-2- methyl-1H-indole-7-carboxylic acid | US10717733, Compound 48 | US11098045, Compound 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24FN3O4S |
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| Mol. Mass. | 445.507 |
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| SMILES | CN(C)S(=O)(=O)c1cccc(c1)-c1c(C)n(C\C(F)=C\CN)c2c(cccc12)C(O)=O |
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| Structure | 
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