| Reaction Details |
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 | Report a problem with these data |
| Target | Lysyl oxidase homolog 2 |
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| Ligand | BDBM454341 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | <300000±n/a nM |
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| Citation |  Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Zhou, W; Robertson, AD Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof US Patent US10717734 Publication Date 7/21/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysyl oxidase homolog 2 |
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| Name: | Lysyl oxidase homolog 2 |
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| Synonyms: | 1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86721.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_115990 |
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| Residue: | 774 |
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| Sequence: | MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRL
AGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGP
IWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLN
IQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGER
TYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVS
CVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSA
SVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDA
GVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQL
GLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAG
VACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFS
SQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLED
TECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEV
AESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
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| BDBM454341 |
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| n/a |
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| Name | BDBM454341 |
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| Synonyms: | US10717734, Compound 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24FN3O2S |
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| Mol. Mass. | 401.498 |
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| SMILES | Cc1c(Cc2cccc(c2)S(C)(=O)=O)c2nc(C)ccc2n1C\C(F)=C\CN |
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| Structure | 
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