| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 8 |
|---|
| Ligand | BDBM50248432 |
|---|
| Substrate/Competitor | n/a |
|---|
| IC50 | 313±n/a nM |
|---|
| Citation |  Chen, D; Song, HY; Sun, ET; Yu, N; Zou, Y Benzimidazole derivatives: preparation and pharmaceutical applications US Patent US10736881 Publication Date 8/11/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 8 |
|---|
| Name: | Histone deacetylase 8 |
|---|
| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41749.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BY41 |
|---|
| Residue: | 377 |
|---|
| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
|
|
|
|---|
| BDBM50248432 |
|---|
| n/a |
|---|
| Name | BDBM50248432 |
|---|
| Synonyms: | CHEMBL521909 | N-hydroxy-3-(1-(3-methoxypropyl)-2-phenethyl-1H-benzo[d]imidazol-5-yl)acrylamide | US10201527, Compound 15 | US10736881, Compound 15 | US8551988, 15 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25N3O3 |
|---|
| Mol. Mass. | 379.4522 |
|---|
| SMILES | COCCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
