| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoic acid receptor gamma |
|---|
| Ligand | BDBM458286 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Transactivation assays |
|---|
| EC50 | 3.40±n/a nM |
|---|
| Citation |  Borthwick, AD; Mills, MT; Brown, JT; Corcoran, JP; De Castro Vasconcelos Goncalves, MB; Kalindjian, SB Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists US Patent US10752616 Publication Date 8/25/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoic acid receptor gamma |
|---|
| Name: | Retinoic acid receptor gamma |
|---|
| Synonyms: | NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50345.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1458016 |
|---|
| Residue: | 454 |
|---|
| Sequence: | MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS
LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK
NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY
ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK
IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH
NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA
LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE
MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
|
|
|
|---|
| BDBM458286 |
|---|
| n/a |
|---|
| Name | BDBM458286 |
|---|
| Synonyms: | US10752616, Code No. BHBA-044 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H13FN2O3S |
|---|
| Mol. Mass. | 368.382 |
|---|
| SMILES | Cc1ccc(C)c2oc(cc12)-c1nsc(n1)-c1ccc(C(O)=O)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
