| Reaction Details |
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 | Report a problem with these data |
| Target | Neprilysin |
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| Ligand | BDBM458416 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Ki | <1.000±n/a nM |
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| Citation |  Hughes, AD; Fenster, E; Fleury, M; Gendron, R; Moran, EJ Neprilysin inhibitors US Patent US10744104 Publication Date 8/18/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neprilysin |
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| Name: | Neprilysin |
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| Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
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| Type: | Enzyme |
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| Mol. Mass.: | 85505.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08473 |
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| Residue: | 750 |
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| Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
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| BDBM458416 |
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| n/a |
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| Name | BDBM458416 |
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| Synonyms: | US10744104, Example 11-2 | US20230285340, Example 11-2 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClFNO6 |
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| Mol. Mass. | 437.846 |
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| SMILES | C[C@@](CO)(C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)C(O)=O)C(O)=O |r| |
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| Structure | 
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