| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Ligand | BDBM463563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition In Vitro Assay |
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| IC50 | 0.530±n/a nM |
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| Citation |  Deng, GG; Huang, D; Jesudason, CD; Odingo, JO Azetidinyloxyphenylpyrrolidine compounds US Patent US10781202 Publication Date 9/22/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
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| Type: | Protein |
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| Mol. Mass.: | 83318.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07343 |
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| Residue: | 736 |
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| Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
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| BDBM463563 |
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| n/a |
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| Name | BDBM463563 |
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| Synonyms: | (2S)-3-[(3S,4)S- 3-[(1R)-1- hydroxyethyl]-4- {4-methoxy-3- [(1-(6- chloropyrimidin- 4-yl)azetidin-3- yl)oxy]phenyl}- 3- methylpyrrolidin- 1-yl]-3- oxopropane-1,2- | US10781202, Example 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31ClN4O6 |
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| Mol. Mass. | 506.979 |
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| SMILES | COc1ccc(cc1OC1CN(C1)c1cc(Cl)ncn1)[C@@H]1CN(C[C@@]1(C)[C@@H](C)O)C(=O)[C@@H](O)CO |r| |
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| Structure | 
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