Reaction Details |
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Target | Monoacylglycerol lipase ABHD6 |
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Ligand | BDBM280528 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Competitive Activity-Based Protein Profiling Assay |
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IC50 | >1000±n/a nM |
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Citation | Buzard, DJ; Shaghafi, MB; Cisar, JS; Grice, CA; Jones, TK; Weber, OD Spirocycle compounds and methods of making and using same US Patent US10781211 Publication Date 9/22/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Monoacylglycerol lipase ABHD6 |
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Name: | Monoacylglycerol lipase ABHD6 |
Synonyms: | ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6 |
Type: | Single-pass type II membrane protein; hydrolase |
Mol. Mass.: | 38216.17 |
Organism: | Mus musculus (mouse) |
Description: | Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells. |
Residue: | 336 |
Sequence: | MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYST
DNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
SFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEV
LENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
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BDBM280528 |
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n/a |
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Name | BDBM280528 |
Synonyms: | US10030020, Example 73 | US10781211, Example 73 |
Type | Small organic molecule |
Emp. Form. | C26H30F9N3O3 |
Mol. Mass. | 603.5203 |
SMILES | FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(cc2N2CC3CCC(C2)O3)C(F)(F)F)CC1)C(F)(F)F |
Structure |
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