Reaction Details |
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Target | Monoglyceride lipase |
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Ligand | BDBM280622 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Competitive Activity-Based Protein Profiling Assay |
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IC50 | <100±n/a nM |
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Citation | Buzard, DJ; Shaghafi, MB; Cisar, JS; Grice, CA; Jones, TK; Weber, OD Spirocycle compounds and methods of making and using same US Patent US10781211 Publication Date 9/22/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Monoglyceride lipase |
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Name: | Monoglyceride lipase |
Synonyms: | MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL) |
Type: | Hydrolase |
Mol. Mass.: | 33391.67 |
Organism: | Mus musculus (mouse) |
Description: | Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells. |
Residue: | 303 |
Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLG
HSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRID
SSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAG
CPP
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BDBM280622 |
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n/a |
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Name | BDBM280622 |
Synonyms: | US10030020, Example 167 | US10781211, Example 167 |
Type | Small organic molecule |
Emp. Form. | C26H30F9N3O4 |
Mol. Mass. | 619.5197 |
SMILES | FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(cc2OCC(=O)N2CCCC2)C(F)(F)F)CC1)C(F)(F)F |
Structure |
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