Ki Summary

Reaction Details

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Target

Prostacyclin receptor

Ligand

BDBM464509

Substrate/Competitor

n/a

Meas. Tech.

HTRF assay

EC50

8.00±n/a nM

Citation

Tran, T; Hayashi, R; Ibarra, JB; Ullman, B; Zou, N Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators US Patent US10793529 Publication Date 10/6/2020

More Info.:

Get all data from this article, Assay Method

Prostacyclin receptor

Name:

Prostacyclin receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

40968.22

Organism:

Homo sapiens (Human)

Description:

The membranes prepared from human platelet were used in binding assay.

Residue:

386

Sequence:

MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC

BDBM464509

n/a

Name

BDBM464509

Synonyms:

2-(((1s,4s)-4-((6-(4- methoxyphenyl)-3-oxo-5- phenyl-1,2,4-triazin-2(3H)- yl)methyl)cyclohexyl) methoxy)acetic acid | US10793529, Compound 69

Type

Small organic molecule

Emp. Form.

C26H29N3O5

Mol. Mass.

463.5256

SMILES

COc1ccc(cc1)-c1nn(C[C@@H]2CC[C@H](COCC(O)=O)CC2)c(=O)nc1-c1ccccc1 |r,wU:12.12,15.16,(-10,4.62,;-10,3.08,;-8.67,2.31,;-7.34,3.08,;-6,2.31,;-6,.77,;-7.34,,;-8.67,.77,;-4.67,,;-3.33,.77,;-2,,;-.67,.77,;.67,,;.67,-1.54,;2,-2.31,;3.33,-1.54,;4.67,-2.31,;6,-1.54,;7.34,-2.31,;8.67,-1.54,;10,-2.31,;8.67,,;3.33,,;2,.77,;-2,-1.54,;-.67,-2.31,;-3.33,-2.31,;-4.67,-1.54,;-6,-2.31,;-7.34,-1.54,;-8.67,-2.31,;-8.67,-3.85,;-7.34,-4.62,;-6,-3.85,)|

Structure