Ki Summary

Reaction Details

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Target

Prostacyclin receptor

Ligand

BDBM464512

Substrate/Competitor

n/a

Meas. Tech.

HTRF assay

EC50

73.0±n/a nM

Citation

Tran, T; Hayashi, R; Ibarra, JB; Ullman, B; Zou, N Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators US Patent US10793529 Publication Date 10/6/2020

More Info.:

Get all data from this article, Assay Method

Prostacyclin receptor

Name:

Prostacyclin receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

40968.22

Organism:

Homo sapiens (Human)

Description:

The membranes prepared from human platelet were used in binding assay.

Residue:

386

Sequence:

MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC

BDBM464512

n/a

Name

BDBM464512

Synonyms:

2-(((1s,4s)-4-((5-(3- chlorophenyl)-3-oxo-6- phenyl-1,2,4-triazin-2(3H)- yl)methyl)cyclohexyl) methoxy)acetic acid | US10793529, Compound 67

Type

Small organic molecule

Emp. Form.

C25H26ClN3O4

Mol. Mass.

467.945

SMILES

OC(=O)COC[C@H]1CC[C@@H](Cn2nc(-c3ccccc3)c(nc2=O)-c2cccc(Cl)c2)CC1 |r,wU:9.9,6.5,(9.34,-.77,;8,,;8,1.54,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;;,1.54,;-1.33,2.31,;-2.67,1.54,;-4,2.31,;-5.33,1.54,;-6.67,2.31,;-6.67,3.85,;-8,4.62,;-9.34,3.85,;-9.34,2.31,;-8,1.54,;-5.33,,;-4,-.77,;-2.67,,;-1.33,-.77,;-6.67,-.77,;-8,,;-9.34,-.77,;-9.34,-2.31,;-8,-3.08,;-8,-4.62,;-6.67,-2.31,;1.33,2.31,;2.67,1.54,)|

Structure