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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile acid receptor | ||
| Ligand | BDBM465477 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Binding Assay | ||
| EC50 | 0.501±n/a nM | ||
| Citation |  Chao, J; Jain, R; Hu, L; Lewis, JG; Baribault, H; Caldwell, J Hormone receptor modulators for treating metabolic conditions and disorders US Patent US10793568 Publication Date 10/6/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile acid receptor | |||
| Name: | Bile acid receptor | ||
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 55916.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96RI1 | ||
| Residue: | 486 | ||
| Sequence: |
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| BDBM465477 | |||
| n/a | |||
| Name | BDBM465477 | ||
| Synonyms: | US10793568, Compound I-127 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H24Cl2N2O5 | ||
| Mol. Mass. | 515.385 | ||
| SMILES | OC(=O)c1ccc(cc1)[N+]1([O-])C[C@@H]2C[C@H]1C[C@H]2OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 |wU:14.14,16.19,wD:12.13,TLB:17:16:9.11:13,10:9:15.16:13,6:9:15.16:13,(-5.76,-.38,;-5.17,-1.8,;-6.11,-3.02,;-3.65,-2,;-2.71,-.78,;-1.18,-.99,;-.59,-2.41,;-1.53,-3.63,;-3.06,-3.43,;.93,-2.61,;.57,-1.12,;.25,-3.85,;1.7,-3.12,;1.83,-.25,;2.13,-1.77,;3.61,-2.64,;3.06,-3.81,;3.56,-5.27,;5.07,-5.56,;5.57,-7.02,;4.69,-8.28,;5.61,-9.51,;7.07,-9.01,;7.05,-7.47,;8.28,-6.54,;9.69,-7.15,;9.88,-8.68,;10.93,-6.22,;10.74,-4.69,;9.32,-4.09,;8.09,-5.02,;6.67,-4.41,;3.15,-8.3,;1.83,-9.09,;1.8,-7.55,)| | ||
| Structure | 
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