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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile acid receptor | ||
| Ligand | BDBM465491 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Binding Assay | ||
| EC50 | 0.794±n/a nM | ||
| Citation |  Chao, J; Jain, R; Hu, L; Lewis, JG; Baribault, H; Caldwell, J Hormone receptor modulators for treating metabolic conditions and disorders US Patent US10793568 Publication Date 10/6/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile acid receptor | |||
| Name: | Bile acid receptor | ||
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 55916.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96RI1 | ||
| Residue: | 486 | ||
| Sequence: |
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| BDBM465491 | |||
| n/a | |||
| Name | BDBM465491 | ||
| Synonyms: | US10793568, Compound I-140 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H23Cl2N3O4 | ||
| Mol. Mass. | 512.385 | ||
| SMILES | Clc1cccc(Cl)c1-c1noc(C2CC2)c1CO[C@@H]1C[C@@H]2C[C@H]1CN2c1ccc2oc(=O)[nH]c2c1 |wU:18.20,22.24,wD:20.23,TLB:17:18:23.24:21,25:24:18.19:21,(10.53,-7.71,;10.08,-6.24,;11.13,-5.11,;10.67,-3.64,;9.17,-3.3,;8.12,-4.43,;6.62,-4.08,;8.58,-5.9,;7.53,-7.03,;7.83,-8.54,;6.48,-9.29,;5.35,-8.24,;3.84,-8.54,;2.68,-9.55,;2.38,-8.04,;6,-6.84,;5.25,-5.5,;3.71,-5.48,;2.96,-4.13,;4,-3.19,;2.4,-3.41,;1.35,-6.08,;1.56,-4.54,;.43,-3.24,;1.33,-2.31,;1.33,-.77,;;,1.54,;1.33,2.31,;1.65,3.82,;3.19,3.98,;3.96,5.31,;3.81,2.57,;2.67,1.54,;2.67,,)| | ||
| Structure | 
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