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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile acid receptor | ||
| Ligand | BDBM465562 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Binding Assay | ||
| EC50 | 0.631±n/a nM | ||
| Citation |  Chao, J; Jain, R; Hu, L; Lewis, JG; Baribault, H; Caldwell, J Hormone receptor modulators for treating metabolic conditions and disorders US Patent US10793568 Publication Date 10/6/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile acid receptor | |||
| Name: | Bile acid receptor | ||
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 55916.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96RI1 | ||
| Residue: | 486 | ||
| Sequence: |
| ||
| BDBM465562 | |||
| n/a | |||
| Name | BDBM465562 | ||
| Synonyms: | US10793568, Compound I-212 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H33Cl2N3O7S | ||
| Mol. Mass. | 674.591 | ||
| SMILES | Clc1cccc(Cl)c1-c1noc(C2CC2)c1CO[C@@H]1C[C@@H]2C[C@H]1CN2c1ccc(cc1)C(=O)NS(=O)(=O)CCOC(=O)C1CC1 |wU:20.23,18.20,wD:22.24,THB:25:24:19.18:21,17:18:24.23:21,(9.88,-8.68,;9.69,-7.15,;10.93,-6.22,;10.74,-4.69,;9.32,-4.09,;8.09,-5.02,;6.67,-4.41,;8.28,-6.54,;7.05,-7.47,;7.07,-9.01,;5.61,-9.51,;4.69,-8.28,;3.15,-8.3,;1.83,-9.09,;1.8,-7.55,;5.57,-7.02,;5.07,-5.56,;3.56,-5.27,;3.06,-3.81,;3.61,-2.64,;2.13,-1.77,;1.83,-.25,;1.7,-3.12,;.25,-3.85,;.93,-2.61,;-.21,-1.58,;.11,-.08,;-1.04,.95,;-2.5,.47,;-2.82,-1.03,;-1.68,-2.06,;-3.65,1.5,;-3.33,3.01,;-5.11,1.02,;-6.26,2.05,;-7.29,.91,;-5.23,3.2,;-7.41,3.08,;-8.87,2.6,;-10.02,3.63,;-11.48,3.15,;-11.8,1.65,;-12.63,4.18,;-14.13,4.5,;-13.1,5.65,)| | ||
| Structure | 
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