Reaction Details |
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Target | NADPH oxidase 1 |
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Ligand | BDBM299743 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ROS Production Measurement on hNOX1 Membranes |
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Ki | 29.0±n/a nM |
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Citation | Machin, P; Sharpe, A; Lock, CJ; Chambers, MS; Hodges, A; Allen, V; Ellard, JM Amido thiadiazole derivatives as NADPH oxidase inhibitors US Patent US10130619 Publication Date 11/20/2018 |
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More Info.: | Get all data from this article, Assay Method |
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NADPH oxidase 1 |
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Name: | NADPH oxidase 1 |
Synonyms: | MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 64890.44 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_792877 |
Residue: | 564 |
Sequence: | MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCL
NFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHL
FNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVI
MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHP
RKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKV
VMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGD
WTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYK
FQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSN
IVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSL
RKCCHRYSSLDPRKVQFYFNKENF
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BDBM299743 |
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n/a |
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Name | BDBM299743 |
Synonyms: | US10130619, Example 9 |
Type | Small organic molecule |
Emp. Form. | C28H29N5O3S |
Mol. Mass. | 515.627 |
SMILES | COc1cc(ccc1O[C@@H](CCN1CCCC1)c1ccccc1)C(=O)Nc1nnc(s1)-c1ccncc1 |r| |
Structure |
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