Reaction Details |
| Report a problem with these data |
Target | NADPH oxidase 1 |
---|
Ligand | BDBM300406 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ROS Production Measurement on hNOX1 Membranes |
---|
Ki | 78.0±n/a nM |
---|
Citation | Machin, P; Sharpe, A; Lock, CJ; Chambers, MS; Hodges, A; Allen, V; Ellard, JM Amido thiadiazole derivatives as NADPH oxidase inhibitors US Patent US10130619 Publication Date 11/20/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
NADPH oxidase 1 |
---|
Name: | NADPH oxidase 1 |
Synonyms: | MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 64890.44 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_792877 |
Residue: | 564 |
Sequence: | MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCL
NFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHL
FNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVI
MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHP
RKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKV
VMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGD
WTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYK
FQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSN
IVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSL
RKCCHRYSSLDPRKVQFYFNKENF
|
|
|
BDBM300406 |
---|
n/a |
---|
Name | BDBM300406 |
Synonyms: | US10130619, Example 149 |
Type | Small organic molecule |
Emp. Form. | C21H18N6OS |
Mol. Mass. | 402.472 |
SMILES | C[C@H](Nc1ccc(cn1)C(=O)Nc1nnc(s1)-c1ccncc1)c1ccccc1 |r| |
Structure |
|