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TargetNADPH oxidase 1
LigandBDBM300408
Substrate/Competitorn/a
Meas. Tech.ROS Production Measurement on hNOX1 Membranes
Ki 38.0±n/a nM
Citation Machin PSharpe ALock CJChambers MSHodges AAllen VEllard JM Amido thiadiazole derivatives as NADPH oxidase inhibitors US Patent  US10130619 Publication Date 11/20/2018
More Info.:Get all data from this article,  Assay Method
 
NADPH oxidase 1
Name:NADPH oxidase 1
Synonyms:MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1
Type:PROTEIN
Mol. Mass.:64890.44
Organism:Homo sapiens (Human)
Description:ChEMBL_792877
Residue:564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCL
NFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHL
FNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVI
MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHP
RKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKV
VMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGD
WTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYK
FQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSN
IVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSL
RKCCHRYSSLDPRKVQFYFNKENF
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BDBM300408
n/a
NameBDBM300408
Synonyms:US10130619, Example 152
TypeSmall organic molecule
Emp. Form.C23H18N4O4S
Mol. Mass.446.478
SMILESCOc1cc(ccc1OC1COc2ccccc12)C(=O)Nc1nnc(s1)-c1ccncc1
Structure
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