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TargetA disintegrin and metalloproteinase with thrombospondin motifs 6
LigandBDBM471902
Substrate/Competitorn/a
Meas. Tech.In Vitro Assay
IC50 12.5±n/a nM
Citation Labéguère, FGHeng, RDe Ceuninck, FAAlvey, LJAmantini, DBrebion, FLDeprez, PMGosmini, RLJary, HMPeixoto, CPop-Botez, IEVarin, ML 5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis US Patent US10829478 Publication Date 11/10/2020
More Info.:Get all data from this article,  Assay Method
 
A disintegrin and metalloproteinase with thrombospondin motifs 6
Name:A disintegrin and metalloproteinase with thrombospondin motifs 6
Synonyms:ADAM-TS 6 | ADAM-TS6 | ADAMTS-6 | ADAMTS6 | ATS6_HUMAN
Type:Protein
Mol. Mass.:125276.26
Organism:Human
Description:Q9UKP5
Residue:1117
Sequence:
MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFT
VKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDG
PQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHF
SYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHH
RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA
RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD
ICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSC
GTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAP
GQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKG
WCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGE
RKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYN
FYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIE
GFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKF
DVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEV
GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP
PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP
PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP
RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNT
EECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH
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  Blast E-value cutoff:
BDBM471902
n/a
NameBDBM471902
Synonyms:(5R)-5-[3-[(3S)- 4-(4-chloro-3- methoxy-phenyl)- 3-methyl- piperazin- 1-yl]-3-oxo- propyl] imidazolidine- 2,4-dione | US10829478, Compound 133
TypeSmall organic molecule
Emp. Form.C18H23ClN4O4
Mol. Mass.394.853
SMILESCOc1cc(ccc1Cl)N1CCN(C[C@@H]1C)C(=O)CC[C@H]1NC(=O)NC1=O |r|
Structure
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