Reaction Details |
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Target | A disintegrin and metalloproteinase with thrombospondin motifs 6 |
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Ligand | BDBM471902 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Assay |
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IC50 | 12.5±n/a nM |
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Citation | Labéguère, FG; Heng, R; De Ceuninck, FA; Alvey, LJ; Amantini, D; Brebion, FL; Deprez, PM; Gosmini, RL; Jary, HM; Peixoto, C; Pop-Botez, IE; Varin, ML 5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis US Patent US10829478 Publication Date 11/10/2020 |
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More Info.: | Get all data from this article, Assay Method |
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A disintegrin and metalloproteinase with thrombospondin motifs 6 |
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Name: | A disintegrin and metalloproteinase with thrombospondin motifs 6 |
Synonyms: | ADAM-TS 6 | ADAM-TS6 | ADAMTS-6 | ADAMTS6 | ATS6_HUMAN |
Type: | Protein |
Mol. Mass.: | 125276.26 |
Organism: | Human |
Description: | Q9UKP5 |
Residue: | 1117 |
Sequence: | MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFT
VKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDG
PQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHF
SYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHH
RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA
RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD
ICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSC
GTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAP
GQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKG
WCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGE
RKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYN
FYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIE
GFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKF
DVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEV
GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP
PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP
PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP
RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNT
EECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH
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BDBM471902 |
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n/a |
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Name | BDBM471902 |
Synonyms: | (5R)-5-[3-[(3S)- 4-(4-chloro-3- methoxy-phenyl)- 3-methyl- piperazin- 1-yl]-3-oxo- propyl] imidazolidine- 2,4-dione | US10829478, Compound 133 |
Type | Small organic molecule |
Emp. Form. | C18H23ClN4O4 |
Mol. Mass. | 394.853 |
SMILES | COc1cc(ccc1Cl)N1CCN(C[C@@H]1C)C(=O)CC[C@H]1NC(=O)NC1=O |r| |
Structure |
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