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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium channel protein type 9 subunit alpha | ||
| Ligand | BDBM50237516 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Ligand Binding Assay (LBA) | ||
| IC50 | 14.0±n/a nM | ||
| Citation |  Wu, Y; Guernon, JM Acyl sulfonamide NaV1.7 inhibitors US Patent US10836758 Publication Date 11/17/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium channel protein type 9 subunit alpha | |||
| Name: | Sodium channel protein type 9 subunit alpha | ||
| Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
| Type: | Protein | ||
| Mol. Mass.: | 226375.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15858 | ||
| Residue: | 1988 | ||
| Sequence: |
| ||
| BDBM50237516 | |||
| n/a | |||
| Name | BDBM50237516 | ||
| Synonyms: | CHEMBL4080712 | US10836758, Example 18 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H22ClFN4O2S2 | ||
| Mol. Mass. | 432.964 | ||
| SMILES | N[C@H]1CC[C@H](CCNc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)CC1 |r,wU:1.0,wD:4.4,(12.18,-61.35,;12.18,-59.81,;10.84,-59.04,;10.84,-57.5,;12.18,-56.73,;12.18,-55.19,;13.5,-54.42,;13.49,-52.86,;14.83,-52.07,;14.83,-50.53,;16.16,-49.76,;16.16,-48.22,;17.49,-50.53,;17.49,-52.07,;16.16,-52.84,;16.16,-54.38,;18.83,-49.74,;18.06,-48.41,;19.6,-48.4,;20.18,-50.51,;21.51,-49.73,;21.5,-48.2,;22.96,-47.73,;23.87,-48.96,;22.97,-50.21,;13.51,-57.5,;13.5,-59.05,)| | ||
| Structure | 
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