| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-tyrosine kinase 6 |
|---|
| Ligand | BDBM473175 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radioisotope Filter Binding Assay |
|---|
| IC50 | 52±n/a nM |
|---|
| Citation |  Mansour, TS; Evans, CE 1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions US Patent US10844038 Publication Date 11/24/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-tyrosine kinase 6 |
|---|
| Name: | Protein-tyrosine kinase 6 |
|---|
| Synonyms: | BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK |
|---|
| Type: | Tyrosine-protein kinase |
|---|
| Mol. Mass.: | 51839.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 451 |
|---|
| Sequence: | MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQG
YVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRD
TQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPH
WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMK
KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGM
CYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS
RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLM
LTCWCRDPEQRPCFKALRERLSSFTSYENPT
|
|
|
|---|
| BDBM473175 |
|---|
| n/a |
|---|
| Name | BDBM473175 |
|---|
| Synonyms: | (3S,4S)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1,2-dithiolan-4-ol | US10844038, Example 46 A. |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H19N5O2S2 |
|---|
| Mol. Mass. | 437.538 |
|---|
| SMILES | Nc1ncnc2n(C[C@@H]3SSC[C@@H]3O)nc(-c3ccc(Oc4ccccc4)cc3)c12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
