| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase acidic protein |
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| Ligand | BDBM474356 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Endonuclease Inhibition Assay (PA FP Assay) |
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| IC50 | 40.0±n/a nM |
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| Citation |  Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent US10858366 Publication Date 12/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase acidic protein |
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| Name: | Polymerase acidic protein |
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| Synonyms: | PA | PA_I75A3 | RNA-directed RNA polymerase subunit P2 |
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| Type: | Protein |
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| Mol. Mass.: | 82806.72 |
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| Organism: | n/a |
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| Description: | P31343 |
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| Residue: | 716 |
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| Sequence: | MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSENTHIHIFSFTGEGMATKADYTLDEESRARIKTRLFTIRQ
EMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNG
CIEGKLSQMSKEVNAKIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPYIVKPHERGINSNYLLSWKQVLAELQDIENEEKIPRTKNM
KKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDS
IWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
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| BDBM474356 |
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| n/a |
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| Name | BDBM474356 |
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| Synonyms: | (S)-6-((S)-(4-fluorophenyl)(m-tolyl)methyl)- 11-hydroxy-5,6-dihydro-10H- imidazo[2',1':3,4]pyrazino[1,2-b]pyridazin-10- one | US10858366, Example 38 | US11453677, Example 38 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19FN4O2 |
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| Mol. Mass. | 402.421 |
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| SMILES | Cc1cccc(c1)[C@@H]([C@H]1Cn2ccnc2-c2c(O)c(=O)cnn12)c1ccc(F)cc1 |r| |
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| Structure | 
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