| Reaction Details |
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 | Report a problem with these data |
| Target | Neuraminidase |
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| Ligand | BDBM474372 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Influenza Virus Neuraminidase Assay (NA Assay) |
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| EC50 | 2300±n/a nM |
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| Citation |  Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent US10858366 Publication Date 12/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuraminidase |
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| Name: | Neuraminidase |
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| Synonyms: | NA | NRAM_I33A0 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49687.56 |
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| Organism: | Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)) |
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| Description: | ChEMBL_881601 |
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| Residue: | 453 |
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| Sequence: | MNPNQKIITIGSICMVVGIISLILQIGNIISIWISHSIQTGNQNHTGICNQGIITYNVVA
GQDSTSVILTGNSSLCPIRGWAIHSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQ
GALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGIS
GPDNGAVAVLKYNGIITETIKSWRKKILRTQESECTCVNGSCFTIMTDGPSNGLASYKIF
KIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGY
ICSGVFGDNPRPKDGPGSCGPVSADGANGVKGFSYRYGNGVWIGRTKSDSSRHGFEMIWD
PNGWTETDSRFSVRQDVVAMTDRSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPEEETI
WTSGSIISFCGVNSDTVDWSWPDGAELPFTIDK
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| BDBM474372 |
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| n/a |
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| Name | BDBM474372 |
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| Synonyms: | (S)-6-benzhydryl-11-hydroxy-3- ((methylamino)methyl)-5,6-dihydro-10H- imidazo[1,2-a]pyrido[2,1-c]pyrazin-10-one | US10858366, Example 61 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N4O2 |
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| Mol. Mass. | 412.4837 |
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| SMILES | CNCc1cnc2-c3c(O)c(=O)ccn3[C@H](Cn12)C(c1ccccc1)c1ccccc1 |r| |
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| Structure | 
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