| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin-like modifier-activating enzyme ATG7 |
|---|
| Ligand | BDBM475988 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| IC50 | <20±n/a nM |
|---|
| Citation |  Adhikari, S; Calderwood, EF; England, DB; Gould, AE; Harrison, SJ; Huang, S; Ma, L ATG7 inhibitors and the uses thereof US Patent US10865208 Publication Date 12/15/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin-like modifier-activating enzyme ATG7 |
|---|
| Name: | Ubiquitin-like modifier-activating enzyme ATG7 |
|---|
| Synonyms: | APG7-like | APG7L | ATG12-activating enzyme E1 ATG7 | ATG7 | ATG7_HUMAN | Autophagy-related protein 7 | Ubiquitin-activating enzyme E1-like protein | hAGP7 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 77955.74 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_939703 |
|---|
| Residue: | 703 |
|---|
| Sequence: | MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLP
ARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGT
ALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEAL
ECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQY
PGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPK
AVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLL
LGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADR
LQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRES
RWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLF
ANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEG
GYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYERE
GFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
|
|
|
|---|
| BDBM475988 |
|---|
| n/a |
|---|
| Name | BDBM475988 |
|---|
| Synonyms: | US10865208, Compound I-46 | [(2R,3S,4R,5R)-5-{4-amino-3-[(2-hydroxyethyl)sulfanyl]-1H-pyrazolo[3,4- d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H18N6O7S2 |
|---|
| Mol. Mass. | 422.437 |
|---|
| SMILES | Nc1ncnc2n(nc(SCCO)c12)[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
