| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Ligand | BDBM476343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | nhibition Assay against Klebsiella pneumoniae LpxC |
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| IC50 | 55±0 nM |
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| Citation |  Teng, M; Nammalwar, B; Taganov, K; Puerta, DT Substituted pyrimidines for treating bacterial infections US Patent US10875832 Publication Date 12/29/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Synonyms: | LPXC_KLEP7 | UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase | UDP-3-O-acyl-GlcNAc deacetylase | lpxC |
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| Type: | Protein |
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| Mol. Mass.: | 34042.19 |
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| Organism: | n/a |
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| Description: | A6T4N9 |
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| Residue: | 305 |
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| Sequence: | MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIIVEVDAPEIPIMDGSAAPFVYLLLDAGI
DELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDASTQRYTLNFSAD
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFEDDAKLPMAFRAP
SMVLA
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| BDBM476343 |
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| n/a |
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| Name | BDBM476343 |
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| Synonyms: | US10875832, Compound 98 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24N4O3 |
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| Mol. Mass. | 416.4724 |
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| SMILES | Oc1c(CNc2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O |
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| Structure | 
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