| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L] |
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| Ligand | BDBM476531 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cellular gamma-Secretase Assay |
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| EC50 | 29.9±n/a nM |
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| Citation |  Bartels, B; Jakob-Roetne, R; Limberg, A; Neidhart, W; Ratni, H; Rodriguez Sarmiento, RM Triazolopyridines US Patent US10875854 Publication Date 12/29/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L] |
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| Name: | Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L] |
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| Synonyms: | A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein | Amyloid-beta precursor protein (PreA4 695) [K595N,M596L] | Isoform APP695 (K595N,M596L) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 78580.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05067-4(K595N,M596L) |
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| Residue: | 695 |
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| Sequence: | MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAV
DKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF
QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLK
KYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVA
EEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL
DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVNLDAEF
RHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGV
VEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
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| BDBM476531 |
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| n/a |
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| Name | BDBM476531 |
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| Synonyms: | 8-methyl-N-((8 endo)-3-(6-methylpyrimidin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl)-5-(2,2,2-trifluoroethoxy)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | US10875854, Example 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24F3N7O |
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| Mol. Mass. | 447.4568 |
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| SMILES | Cc1cc(ncn1)N1C[C@@H]2CC[C@H](C1)[C@H]2Nc1nc2c(C)ccc(OCC(F)(F)F)n2n1 |r,TLB:3:7:14:11.10,15:14:7.8.13:11.10| |
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| Structure | 
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